RESUMO
A 35-year-old man presented with a solitary, large, 15 cm × 25 cm, oval annular plaque with a characteristic peripheral keratotic ridge with a central groove on his back [Figure 1]. Besides, there were two round ulcerated overgrowths with a verrucous surface present along the inferior margin of the plaque. Further, there were multiple hyperkeratotic elongated horny eruptions distributed on the primary lesion. Biopsy from the margin of the primary plaque showed cornoid lamella (column of parakeratotic cells overlying a zone of hypogranulosis) confirming porokeratosis while a biopsy from the ulcerated lesion showed keratin pearls, atypical keratinocytes with hyperchromatic nucleus and numerous mitotic figures suggestive of squamous cell carcinoma.
RESUMO
Objective: To describe various delayed cutaneous findings associated with hand, foot, and mouth disease (HFMD). Methods: Patients presenting with clinical features of HFMD were followed-up prospectively for a period of 3 months for the occurrence of delayed cutaneous manifestations. Results: Out of 68 patients on regular follow-up, 23 (33.8%) showed different types of skin and nail changes following HFMD. Nineteen showed features of onychomadesis, 9 developed nail discoloration, and Beau’s line was noted in 5 patients. Cutaneous desquamation was seen in 7 patients. Spontaneous re-growth of nails occurred in all cases within 12 weeks follow-up. Skin desquamation subsided by 2-4 weeks. Conclusion: Delayed cutaneous findings following HFMD are common.
Assuntos
Criança , Masculino , Hipopigmentação/congênito , Hipopigmentação/epidemiologia , Hipopigmentação/genética , Hiperpigmentação/congênito , Hiperpigmentação/epidemiologia , Hiperpigmentação/genética , Masculino , Doenças do Sistema Nervoso/epidemiologia , Transtornos da Pigmentação/congênito , Transtornos da Pigmentação/epidemiologia , Transtornos da Pigmentação/genéticaRESUMO
Phakomatosis pigmentovascularis (PPV) is a rare combination of pigmentary and vascular components with or without systemic involvement. We report here a rare association of Sturge-Weber syndrome, Klippel-Trenaunay syndrome, and PPV type IIb in a 15-year-old boy who had right upper limb monoparesis along with a history of recurrent convulsions.
Assuntos
Adolescente , Humanos , Síndrome de Klippel-Trenaunay-Weber/complicações , Síndrome de Klippel-Trenaunay-Weber/epidemiologia , Masculino , Fenótipo , Transtornos da Pigmentação/complicações , Mancha Vinho do Porto/complicações , Síndrome de Sturge-Weber/epidemiologia , Síndrome de Sturge-Weber/etiologiaRESUMO
Waardenburg syndrome (WS) is a rare autosomally inherited and genetically heterogeneous disorder of neural crest cell development with distinct cutaneous manifestations. Based on the clinical presentations, four subtypes of the disease are recognized. A careful clinical evaluation is required to differentiate various types of WS and other associated auditory-pigmentary syndromes. We describe a case series of WS to highlight the wide spectrum of manifestations of the syndrome including a rare association.